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In 2017 Save the Ta-tas® was able to help fight breast cancer by funding important research at City of Hope. Stay tuned to see what Save the Ta-tas® has in store for 2018. Read more about our most recent contribution below. Save the Ta-tas® has been faithfully funding research since 2004.
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Here’s more about this amazing research:
Precision Genomic Medicine in Treatment of Metastatic Triple Negative Breast Cancer
Yuan Yuan, M.D., Ph.D.
Assistant Professor, Medical Oncology and Therapeutics Research
Dr. Yuan Yuan aims to understand the molecular evolution of treatment-resistant triple-negative breast cancer (TNBC) in order to develop novel therapeutics based on the precise molecular features of each individual’s tumor. TNBC is a biologically aggressive and heterogeneous disease with four subtypes, each representing a unique underlying biology. Treatment of metastatic TNBC has been challenging due to the absence of well-defined molecular targets; therefore, extensive genomic and biological subtype analyses of breast cancers are urgently needed.
The donation gift from Save the Ta-tas® Foundation will assist Dr. Yuan in addressing the challenges of identifying why some breast cancers become metastatic. The proposed novel combination therapy she is planning to develop will revolutionize current treatment regimens through its profound shift from toxic chemotherapy to more effective targeted therapy that is expected to improve clinical outcomes, quality of life and survival.
Successful completion of the proposed study will provide a truly effective combination therapy targeting a highly prevalent molecular pathway. The gift from Save the Ta-tas® Foundation will have a significant impact on pioneering a preclinical model that would advance Dr. Yuan’s understanding of the molecular heterogeneity of TNBC and help her predict treatment responses.
About Yuan Yuan, M.D., Ph.D.
Assistant Professor Yuan Yuan joined the Department of Medical Oncology & Therapeutics in 2012. Dr. Yuan came to City of Hope from Loma Linda University Medical Center where she was an assistant professor in the Division of Medical Oncology and Hematology, and a principal investigator for multiple breast cancer trials.
Dr. Yuan received her bachelor of medicine degree from Xuzhou Medical College in Xuzhou, China, and an M.S. in oncology from Peking Union Medical College in Beijing, China. She went on to complete a Ph.D. in biochemistry and molecular biology from the University of California, Riverside. She then completed a research fellowship at the Scripps Research Institute in La Jolla, CA, followed by an internship and residency in internal medicine at the New York Downtown Hospital in New York, NY. She furthered her training with a hematology and oncology fellowship at the New York University Medical Center, under the direction of Dr. Franco Muggia.
Dr. Yuan has published more than 10 articles in the peer-reviewed literature and has been invited to present at national and international meetings. She is board certified in internal medicine, hematology and oncology. She is currently a NIH K-12 scholar and recipient of NIH R03 grant.